Immunosenescence of Human Natural Killer Cells
نویسندگان
چکیده
منابع مشابه
Immunosenescence of Human Natural Killer Cells
Natural killer (NK) cells are a key component of innate immunity involved not only in the elimination of virus-infected or tumor cells but also in the regulation of the immune response by producing cytokines and chemokines that can activate other cellular components of innate and adaptive immunity. NK cell subsets are differentially affected by aging. Whereas CD56 bright cells are decreased in ...
متن کاملImmunosenescence of human natural killer cells.
Natural killer (NK) cells are a key component of innate immunity involved not only in the elimination of virus-infected or tumor cells but also in the regulation of the immune response by producing cytokines and chemokines that can activate other cellular components of innate and adaptive immunity. NK cell subsets are differentially affected by aging. Whereas CD56(bright) cells are decreased in...
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Background: Invariant natural killer cells (iNKT) are an important immunoregulatory T cell subset. Currently several flow cytometry-based approaches exist for the identifi-cation of iNKT cells, which rely on using the 6B11 monoclonal antibody or a combina-tion of anti-Vα24 and anti-Vβ11 antibodies. Objective: The aim of this study was to compare the ability of two flow cytometry-based methods f...
متن کاملHuman natural killer cells.
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration. During the past 2 decades there has been a substantial gain in ou...
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Granulocytes and monocytes are known to phagocytose and kill numerous varieties of bacteria and parasites. This function is intimately associated with an early event called the "respiratory burst," which includes the generation of 02and H202 (1). These and other highly reactive molecular species can easily be detected in the presence of luminol or other readily oxidized substrates by the emissi...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2011
ISSN: 1662-8128,1662-811X
DOI: 10.1159/000328005